5UEN

Crystal structure of the human adenosine A1 receptor A1AR-bRIL in complex with the covalent antagonist DU172 at 3.2A resolution

5UEN の概要

• エントリーDOI: 10.2210/pdb5uen/pdb
• 分子名称: Adenosine receptor A1,Soluble cytochrome b562,Adenosine receptor A1, 4-{[3-(8-cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-3H-purin-3-yl)propyl]carbamoyl}benzene-1-sulfonyl fluoride, OLEIC ACID (3 entities in total)
• 機能のキーワード: gpcr, transmembrane, receptor, adenosine, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96136.47

構造登録者

Glukhova, A.,Thal, D.M.,Nguyen, A.T.,Vecchio, E.A.,Jorg, M.,Scammells, P.J.,May, L.T.,Sexton, P.M.,Christopoulos, A. (登録日: 2017-01-03, 公開日: 2017-03-01, 最終更新日: 2023-10-04)

• 主引用文献: Glukhova, A.,Thal, D.M.,Nguyen, A.T.,Vecchio, E.A.,Jorg, M.,Scammells, P.J.,May, L.T.,Sexton, P.M.,Christopoulos, A.; Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity.; Cell, 168:867-877.e13, 2017; PubMed: 28235198; DOI: 10.1016/j.cell.2017.01.042

実験手法

X-RAY DIFFRACTION (3.2 Å)