5UAH
Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant
Summary for 5UAH
Entry DOI | 10.2210/pdb5uah/pdb |
Related | 5UAC 5UAG 5UAJ 5UAL 5UAQ |
Descriptor | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total) |
Functional Keywords | inhibitor, antibiotic, tuberculosis, rifampin, rifamycin, rna polymerase, rpob d516v mutant, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Escherichia coli (strain K12) More |
Total number of polymer chains | 12 |
Total formula weight | 920963.50 |
Authors | Molodtsov, V.,Scharf, N.T.,Stefan, M.A.,Garcia, G.A.,Murakami, K.S. (deposition date: 2016-12-19, release date: 2017-01-11, Last modification date: 2023-10-04) |
Primary citation | Molodtsov, V.,Scharf, N.T.,Stefan, M.A.,Garcia, G.A.,Murakami, K.S. Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Mol. Microbiol., 103:1034-1045, 2017 Cited by PubMed: 28009073DOI: 10.1111/mmi.13606 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.1 Å) |
Structure validation
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