5U8F
Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine
Summary for 5U8F
Entry DOI | 10.2210/pdb5u8f/pdb |
Related | 5u8a |
Descriptor | Polycomb protein EED, (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine (3 entities in total) |
Functional Keywords | wd40 prc2, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O75530 |
Total number of polymer chains | 1 |
Total formula weight | 42960.98 |
Authors | Jakob, C.G.,Zhu, H. (deposition date: 2016-12-14, release date: 2017-03-15, Last modification date: 2023-10-04) |
Primary citation | Curtin, M.L.,Pliushchev, M.A.,Li, H.Q.,Torrent, M.,Dietrich, J.D.,Jakob, C.G.,Zhu, H.,Zhao, H.,Wang, Y.,Ji, Z.,Clark, R.F.,Sarris, K.A.,Selvaraju, S.,Shaw, B.,Algire, M.A.,He, Y.,Richardson, P.L.,Sweis, R.F.,Sun, C.,Chiang, G.G.,Michaelides, M.R. SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg. Med. Chem. Lett., 27:1576-1583, 2017 Cited by PubMed: 28254486DOI: 10.1016/j.bmcl.2017.02.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.343 Å) |
Structure validation
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