5U89

Crystal structure of a cross-module fragment from the dimodular NRPS DhbF

Summary for 5U89

Entry DOI	10.2210/pdb5u89/pdb
Descriptor	Amino acid adenylation domain protein, MbtH domain protein, 5'-({[(2R)-3-amino-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}propyl]sulfonyl}amino)-5'-deoxyadenosine (3 entities in total)
Functional Keywords	nonribosomal peptide synthetase, mbth-like protein, mechanism-based inhibitor, megaenzyme, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Geobacillus sp. More
Total number of polymer chains	2
Total formula weight	131335.11
Authors	Tarry, M.J.,Schmeing, T.M. (deposition date: 2016-12-14, release date: 2017-05-10, Last modification date: 2020-01-08)
Primary citation	Tarry, M.J.,Haque, A.S.,Bui, K.H.,Schmeing, T.M. X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture. Structure, 25:783-793.e4, 2017 Cited by PubMed: 28434915 DOI: 10.1016/j.str.2017.03.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.075 Å)

Structure validation