5U89

Crystal structure of a cross-module fragment from the dimodular NRPS DhbF

5U89 の概要

• エントリーDOI: 10.2210/pdb5u89/pdb
• 分子名称: Amino acid adenylation domain protein, MbtH domain protein, 5'-({[(2R)-3-amino-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}propyl]sulfonyl}amino)-5'-deoxyadenosine (3 entities in total)
• 機能のキーワード: nonribosomal peptide synthetase, mbth-like protein, mechanism-based inhibitor, megaenzyme, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Geobacillus sp.; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 131335.11

構造登録者

Tarry, M.J.,Schmeing, T.M. (登録日: 2016-12-14, 公開日: 2017-05-10, 最終更新日: 2020-01-08)

• 主引用文献: Tarry, M.J.,Haque, A.S.,Bui, K.H.,Schmeing, T.M.; X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture.; Structure, 25:783-793.e4, 2017; PubMed: 28434915; DOI: 10.1016/j.str.2017.03.014

実験手法

X-RAY DIFFRACTION (3.075 Å)