5U7M

Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom

5U7M の概要

• エントリーDOI: 10.2210/pdb5u7m/pdb
• 関連するPDBエントリー: 5U7O
• 分子名称: Envelope glycoprotein gp160, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (15 entities in total)
• 機能のキーワード: hiv-1 entry, small molecule, inhibitor, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 180977.01

構造登録者

Pancera, M.,Lai, Y.-T.,Kwong, P.D. (登録日: 2016-12-12, 公開日: 2017-08-30, 最終更新日: 2020-07-29)

• 主引用文献: Pancera, M.,Lai, Y.T.,Bylund, T.,Druz, A.,Narpala, S.,O'Dell, S.,Schon, A.,Bailer, R.T.,Chuang, G.Y.,Geng, H.,Louder, M.K.,Rawi, R.,Soumana, D.I.,Finzi, A.,Herschhorn, A.,Madani, N.,Sodroski, J.,Freire, E.,Langley, D.R.,Mascola, J.R.,McDermott, A.B.,Kwong, P.D.; Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.; Nat. Chem. Biol., 13:1115-1122, 2017; PubMed: 28825711; DOI: 10.1038/nchembio.2460

実験手法

X-RAY DIFFRACTION (3.025 Å)