5U7M
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom
5U7M の概要
エントリーDOI | 10.2210/pdb5u7m/pdb |
関連するPDBエントリー | 5U7O |
分子名称 | Envelope glycoprotein gp160, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (15 entities in total) |
機能のキーワード | hiv-1 entry, small molecule, inhibitor, viral protein-immune system complex, viral protein/immune system |
由来する生物種 | Human immunodeficiency virus 1 詳細 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 180977.01 |
構造登録者 | |
主引用文献 | Pancera, M.,Lai, Y.T.,Bylund, T.,Druz, A.,Narpala, S.,O'Dell, S.,Schon, A.,Bailer, R.T.,Chuang, G.Y.,Geng, H.,Louder, M.K.,Rawi, R.,Soumana, D.I.,Finzi, A.,Herschhorn, A.,Madani, N.,Sodroski, J.,Freire, E.,Langley, D.R.,Mascola, J.R.,McDermott, A.B.,Kwong, P.D. Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529. Nat. Chem. Biol., 13:1115-1122, 2017 Cited by PubMed: 28825711DOI: 10.1038/nchembio.2460 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.025 Å) |
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