5U73

Crystal structure of human Niemann-Pick C1 protein

Replaces:  5I31

Summary for 5U73

• Entry DOI: 10.2210/pdb5u73/pdb
• Related: 5U74
• Descriptor: Niemann-Pick C1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: membrane protein
• Biological source: Homo sapiens (Human)
• Cellular location: Late endosome membrane ; Multi-pass membrane protein : O15118
• Total number of polymer chains: 1
• Total formula weight: 145622.01

Authors

Li, X.,Wang, J.,Blobel, G. (deposition date: 2016-12-11, release date: 2017-09-27, Last modification date: 2020-07-29)

• Primary citation: Li, X.,Lu, F.,Trinh, M.N.,Schmiege, P.,Seemann, J.,Wang, J.,Blobel, G.; 3.3 angstrom structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.; Proc. Natl. Acad. Sci. U.S.A., 114:9116-9121, 2017; PubMed: 28784760; DOI: 10.1073/pnas.1711716114

Experimental method

X-RAY DIFFRACTION (3.348 Å)