5U6C
Crystal structure of the Mer kinase domain in complex with a macrocyclic inhibitor
Summary for 5U6C
Entry DOI | 10.2210/pdb5u6c/pdb |
Related | 5U6B |
Descriptor | Tyrosine-protein kinase Mer, (10R)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1H-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one (3 entities in total) |
Functional Keywords | kinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane ; Single-pass type I membrane protein : Q12866 |
Total number of polymer chains | 2 |
Total formula weight | 73393.22 |
Authors | Gajiwala, K.S.,Ferre, R.A. (deposition date: 2016-12-07, release date: 2017-07-26, Last modification date: 2023-10-04) |
Primary citation | Gajiwala, K.S.,Grodsky, N.,Bolanos, B.,Feng, J.,Ferre, R.,Timofeevski, S.,Xu, M.,Murray, B.W.,Johnson, T.W.,Stewart, A. The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase. J. Biol. Chem., 292:15705-15716, 2017 Cited by PubMed: 28724631DOI: 10.1074/jbc.M116.771485 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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