5U5T
Crystal structure of EED in complex with H3K27Me3 peptide and 3-(benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide
Summary for 5U5T
Entry DOI | 10.2210/pdb5u5t/pdb |
Related | 5U5H 5U5K 5U62 |
Descriptor | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, (3R)-3-[(2H-1,3-benzodioxol-4-yl)methyl]piperidine-1-carboximidamide, ... (5 entities in total) |
Functional Keywords | eed, fragment-based generation, oncology, transcription-transferase complex, transcription/transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: O75530 Q15910 |
Total number of polymer chains | 4 |
Total formula weight | 92915.63 |
Authors | Bussiere, D.,Shu, W. (deposition date: 2016-12-07, release date: 2017-01-11, Last modification date: 2024-03-06) |
Primary citation | Lingel, A.,Sendzik, M.,Huang, Y.,Shultz, M.D.,Cantwell, J.,Dillon, M.P.,Fu, X.,Fuller, J.,Gabriel, T.,Gu, J.,Jiang, X.,Li, L.,Liang, F.,McKenna, M.,Qi, W.,Rao, W.,Sheng, X.,Shu, W.,Sutton, J.,Taft, B.,Wang, L.,Zeng, J.,Zhang, H.,Zhang, M.,Zhao, K.,Lindvall, M.,Bussiere, D.E. Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem., 60:415-427, 2017 Cited by PubMed: 27992714DOI: 10.1021/acs.jmedchem.6b01473 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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