5U5L

X-ray Crystal Structure of the PPARgamma Ligand Binding Domain in Complex with Rivoglitazone

5U5L の概要

• エントリーDOI: 10.2210/pdb5u5l/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (5S)-5-({4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione (3 entities in total)
• 機能のキーワード: nuclear receptor, peroxisome proliferator activated receptor, rivoglitazone, tzd, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62813.92

構造登録者

Bruning, J.B.,Rajapaksha, H.,Wegener, K.,Bhatia, H. (登録日: 2016-12-06, 公開日: 2017-08-23, 最終更新日: 2023-10-04)

• 主引用文献: Rajapaksha, H.,Bhatia, H.,Wegener, K.,Petrovsky, N.,Bruning, J.B.; X-ray crystal structure of rivoglitazone bound to PPAR gamma and PPAR subtype selectivity of TZDs.; Biochim. Biophys. Acta, 1861:1981-1991, 2017; PubMed: 28499821; DOI: 10.1016/j.bbagen.2017.05.008

実験手法

X-RAY DIFFRACTION (2.55 Å)