5U4G
Wild-type Transthyretin in complex with 2-Boronic Acid-1-[(1E)-2-(3-boronic acid)ethenyl]-4-chlorobenzene
Summary for 5U4G
Entry DOI | 10.2210/pdb5u4g/pdb |
Related | 5U48 5U49 5U4A 5U4B 5U4C 5U4D 5U4E 5U4F |
Descriptor | Transthyretin, (3-{(E)-2-[2-chloro-4-(hydroxyboranyl)phenyl]ethenyl}phenyl)boronic acid (3 entities in total) |
Functional Keywords | boronic acids, medicinal chemistry, stilbene, covalent ligand, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 28389.77 |
Authors | Windsor, I.W.,Smith, T.P.,Raines, R.T.,Forest, K.T. (deposition date: 2016-12-03, release date: 2017-09-27, Last modification date: 2023-10-04) |
Primary citation | Smith, T.P.,Windsor, I.W.,Forest, K.T.,Raines, R.T. Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. J. Med. Chem., 60:7820-7834, 2017 Cited by PubMed: 28920684DOI: 10.1021/acs.jmedchem.7b00952 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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