5U4G

Wild-type Transthyretin in complex with 2-Boronic Acid-1-[(1E)-2-(3-boronic acid)ethenyl]-4-chlorobenzene

Summary for 5U4G

• Entry DOI: 10.2210/pdb5u4g/pdb
• Related: 5U48 5U49 5U4A 5U4B 5U4C 5U4D 5U4E 5U4F
• Descriptor: Transthyretin, (3-{(E)-2-[2-chloro-4-(hydroxyboranyl)phenyl]ethenyl}phenyl)boronic acid (3 entities in total)
• Functional Keywords: boronic acids, medicinal chemistry, stilbene, covalent ligand, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 28389.77

Authors

Windsor, I.W.,Smith, T.P.,Raines, R.T.,Forest, K.T. (deposition date: 2016-12-03, release date: 2017-09-27, Last modification date: 2023-10-04)

• Primary citation: Smith, T.P.,Windsor, I.W.,Forest, K.T.,Raines, R.T.; Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation.; J. Med. Chem., 60:7820-7834, 2017; PubMed: 28920684; DOI: 10.1021/acs.jmedchem.7b00952

Experimental method

X-RAY DIFFRACTION (1.8 Å)