5U3F

Structure of Mycobacterium tuberculosis IlvE, a branched-chain amino acid transaminase, in complex with D-cycloserine derivative

5U3F の概要

• エントリーDOI: 10.2210/pdb5u3f/pdb
• 分子名称: Branched-chain-amino-acid aminotransferase, (5-hydroxy-6-methyl-4-{[(3-oxo-2,3-dihydro-1,2-oxazol-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate (3 entities in total)
• 機能のキーワード: branched-chain amino acid transaminase, amino acid biosynthesis, pyridoxal phosphate, inhibitor, d-cycloserine, transferase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80076.26

構造登録者

Favrot, L.,Amorim Franco, T.M.,Blanchard, J.S. (登録日: 2016-12-02, 公開日: 2017-03-22, 最終更新日: 2023-10-04)

• 主引用文献: Amorim Franco, T.M.,Favrot, L.,Vergnolle, O.,Blanchard, J.S.; Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine.; ACS Chem. Biol., 12:1235-1244, 2017; PubMed: 28272868; DOI: 10.1021/acschembio.7b00142

実験手法

X-RAY DIFFRACTION (1.695 Å)