5U2M

Crystal structure of human NAMPT with A-1293201

5U2M の概要

• エントリーDOI: 10.2210/pdb5u2m/pdb
• 関連するPDBエントリー: 5U2N
• 分子名称: Nicotinamide phosphoribosyltransferase, N-[4-({[(3S)-oxolan-3-yl]methyl}carbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: nampt inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P43490
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 109547.93

構造登録者

Longenecker, K.L.,Raich, D.,Korepanova, A.V. (登録日: 2016-11-30, 公開日: 2017-06-28, 最終更新日: 2023-10-04)

• 主引用文献: Wilsbacher, J.L.,Cheng, M.,Cheng, D.,Trammell, S.A.J.,Shi, Y.,Guo, J.,Koeniger, S.L.,Kovar, P.J.,He, Y.,Selvaraju, S.,Heyman, H.R.,Sorensen, B.K.,Clark, R.F.,Hansen, T.M.,Longenecker, K.L.,Raich, D.,Korepanova, A.V.,Cepa, S.,Towne, D.L.,Abraham, V.C.,Tang, H.,Richardson, P.L.,McLoughlin, S.M.,Badagnani, I.,Curtin, M.L.,Michaelides, M.R.,Maag, D.,Buchanan, F.G.,Chiang, G.G.,Gao, W.,Rosenberg, S.H.,Brenner, C.,Tse, C.; Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.; Mol. Cancer Ther., 16:1236-1245, 2017; PubMed: 28468779; DOI: 10.1158/1535-7163.MCT-16-0819

実験手法

X-RAY DIFFRACTION (1.89 Å)