5U1M
Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor
Summary for 5U1M
Entry DOI | 10.2210/pdb5u1m/pdb |
Descriptor | Insulin receptor substrate 1, Insulin receptor (3 entities in total) |
Functional Keywords | ptb domain, insulin receptor substrate-1, phosphopeptide, insulin receptor, protein binding |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P06213 |
Total number of polymer chains | 2 |
Total formula weight | 12923.84 |
Authors | |
Primary citation | Cai, W.,Sakaguchi, M.,Kleinridders, A.,Gonzalez-Del Pino, G.,Dreyfuss, J.M.,O'Neill, B.T.,Ramirez, A.K.,Pan, H.,Winnay, J.N.,Boucher, J.,Eck, M.J.,Kahn, C.R. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun, 8:14892-14892, 2017 Cited by PubMed: 28345670DOI: 10.1038/ncomms14892 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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