5U1M

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

Summary for 5U1M

• Entry DOI: 10.2210/pdb5u1m/pdb
• Descriptor: Insulin receptor substrate 1, Insulin receptor (3 entities in total)
• Functional Keywords: ptb domain, insulin receptor substrate-1, phosphopeptide, insulin receptor, protein binding
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P06213
• Total number of polymer chains: 2
• Total formula weight: 12923.84

Authors

Eck, M.J.,Dhe-Paganon, S. (deposition date: 2016-11-28, release date: 2017-09-13)

• Primary citation: Cai, W.,Sakaguchi, M.,Kleinridders, A.,Gonzalez-Del Pino, G.,Dreyfuss, J.M.,O'Neill, B.T.,Ramirez, A.K.,Pan, H.,Winnay, J.N.,Boucher, J.,Eck, M.J.,Kahn, C.R.; Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.; Nat Commun, 8:14892-14892, 2017; PubMed: 28345670; DOI: 10.1038/ncomms14892

Experimental method

X-RAY DIFFRACTION (1.8 Å)