5U1M

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

5U1M の概要

• エントリーDOI: 10.2210/pdb5u1m/pdb
• 分子名称: Insulin receptor substrate 1, Insulin receptor (3 entities in total)
• 機能のキーワード: ptb domain, insulin receptor substrate-1, phosphopeptide, insulin receptor, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P06213
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 12923.84

構造登録者

Eck, M.J.,Dhe-Paganon, S. (登録日: 2016-11-28, 公開日: 2017-09-13)

• 主引用文献: Cai, W.,Sakaguchi, M.,Kleinridders, A.,Gonzalez-Del Pino, G.,Dreyfuss, J.M.,O'Neill, B.T.,Ramirez, A.K.,Pan, H.,Winnay, J.N.,Boucher, J.,Eck, M.J.,Kahn, C.R.; Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.; Nat Commun, 8:14892-14892, 2017; PubMed: 28345670; DOI: 10.1038/ncomms14892

実験手法

X-RAY DIFFRACTION (1.8 Å)