5TWU

Structure of Maternal Embryonic Leucine Zipper Kinase

Summary for 5TWU

Entry DOI	10.2210/pdb5twu/pdb
Related	5TVT 5TWL 5TWY 5TWZ
Descriptor	Maternal embryonic leucine zipper kinase (2 entities in total)
Functional Keywords	kinase inhibitor, basal-like breast cancer, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	79313.91
Authors	Li, Q.,Seo, H.-S.,Huang, H.-T.,Gray, N.S.,Dhe-Paganon, S.,Eck, M.J. (deposition date: 2016-11-14, release date: 2017-11-22, Last modification date: 2023-10-04)
Primary citation	Huang, H.T.,Seo, H.S.,Zhang, T.,Wang, Y.,Jiang, B.,Li, Q.,Buckley, D.L.,Nabet, B.,Roberts, J.M.,Paulk, J.,Dastjerdi, S.,Winter, G.E.,McLauchlan, H.,Moran, J.,Bradner, J.E.,Eck, M.J.,Dhe-Paganon, S.,Zhao, J.J.,Gray, N.S. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife, 6:-, 2017 Cited by PubMed: 28926338 DOI: 10.7554/eLife.26693 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.603 Å)

Structure validation