5TW3
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a Non-nucleoside Inhibitor
Summary for 5TW3
Entry DOI | 10.2210/pdb5tw3/pdb |
Related | 4WE1 |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-7-fluoronaphthalene-2-carbonitrile, ... (5 entities in total) |
Functional Keywords | polymerase, reverse transcriptase, hiv, non-nucleoside inhibitor, transferase, hydrolase-dna-inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 2 |
Total formula weight | 114488.41 |
Authors | Chan, A.H.,Anderson, K.S. (deposition date: 2016-11-11, release date: 2017-03-15, Last modification date: 2023-10-04) |
Primary citation | Kudalkar, S.N.,Beloor, J.,Chan, A.H.,Lee, W.G.,Jorgensen, W.L.,Kumar, P.,Anderson, K.S. Structural and Preclinical Studies of Computationally Designed Non-Nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection. Mol. Pharmacol., 91:383-391, 2017 Cited by PubMed: 28167742DOI: 10.1124/mol.116.107755 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.853 Å) |
Structure validation
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