5TVS

JMJD2A in complex with Ni(II)

5TVS の概要

• エントリーDOI: 10.2210/pdb5tvs/pdb
• 関連するPDBエントリー: 5TVR
• 分子名称: Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION (3 entities in total)
• 機能のキーワード: oxidoreductase demethylase monooxygenase epigenetics, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83783.29

構造登録者

Cascella, B.,Lee, S.G.,Jez, J.M. (登録日: 2016-11-09, 公開日: 2017-02-01, 最終更新日: 2024-11-06)

主引用文献

Cascella, B.,Lee, S.G.,Singh, S.,Jez, J.M.,Mirica, L.M.
The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53:2174-2177, 2017

PubMed Abstract: JIB-04, a specific inhibitor of the O-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O in KDM4A/JMJD2A through a continuous O-consumption assay, X-ray crystal structure data, and molecular docking.

PubMed: 28144654
DOI: 10.1039/c6cc09882g

実験手法

X-RAY DIFFRACTION (2.745 Å)