5TVJ

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with CoA and inhibitor 2k*: 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium

Summary for 5TVJ

• Entry DOI: 10.2210/pdb5tvj/pdb
• Descriptor: Enhanced intracellular survival protein, COENZYME A, 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium, ... (6 entities in total)
• Functional Keywords: transferase, acetyltransferase, resistance, aminoglycoside, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 47239.58

Authors

Gajadeera, C.S.,Garzan, A.,Hou, C.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2016-11-09, release date: 2017-03-01, Last modification date: 2023-10-04)

• Primary citation: Garzan, A.,Willby, M.J.,Ngo, H.X.,Gajadeera, C.S.,Green, K.D.,Holbrook, S.Y.,Hou, C.,Posey, J.E.,Tsodikov, O.V.,Garneau-Tsodikova, S.; Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors.; ACS Infect Dis, 3:302-309, 2017; PubMed: 28192916; DOI: 10.1021/acsinfecdis.6b00193

Experimental method

X-RAY DIFFRACTION (2.3 Å)