5TVJ

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with CoA and inhibitor 2k*: 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium

5TVJ の概要

• エントリーDOI: 10.2210/pdb5tvj/pdb
• 分子名称: Enhanced intracellular survival protein, COENZYME A, 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium, ... (6 entities in total)
• 機能のキーワード: transferase, acetyltransferase, resistance, aminoglycoside, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47239.58

構造登録者

Gajadeera, C.S.,Garzan, A.,Hou, C.,Garneau-Tsodikova, S.,Tsodikov, O.V. (登録日: 2016-11-09, 公開日: 2017-03-01, 最終更新日: 2023-10-04)

• 主引用文献: Garzan, A.,Willby, M.J.,Ngo, H.X.,Gajadeera, C.S.,Green, K.D.,Holbrook, S.Y.,Hou, C.,Posey, J.E.,Tsodikov, O.V.,Garneau-Tsodikova, S.; Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors.; ACS Infect Dis, 3:302-309, 2017; PubMed: 28192916; DOI: 10.1021/acsinfecdis.6b00193

実験手法

X-RAY DIFFRACTION (2.3 Å)