5TV3

Crystal structure of the complex of Helicobacter pylori alpha-carbonic anhydrase with (E)-5-(((4-(tert-butyl)phenyl)sulfonyl)imino)-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide

5TV3 の概要

• エントリーDOI: 10.2210/pdb5tv3/pdb
• 関連するPDBエントリー: 5TT3 5TT8 5TUO
• 分子名称: Alpha-carbonic anhydrase, ZINC ION, (5Z)-5-{[(4-tert-butylphenyl)sulfonyl]imino}-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide, ... (5 entities in total)
• 機能のキーワード: alpha-carbonic anhydrase, helicobacter pylori, lyase, zinc-metalloenzyme, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Helicobacter pylori (strain ATCC 700392 / 26695)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 219823.05

構造登録者

Modak, J.K.,Roujeinikova, A. (登録日: 2016-11-07, 公開日: 2017-09-20, 最終更新日: 2023-10-04)

• 主引用文献: Modak, J.K.,Liu, Y.C.,Supuran, C.T.,Roujeinikova, A.; Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.; J. Med. Chem., 59:11098-11109, 2016; PubMed: 28002963; DOI: 10.1021/acs.jmedchem.6b01333

実験手法

X-RAY DIFFRACTION (2.9 Å)