5TUZ

Structure of human GLP SET-domain (EHMT1) in complex with inhibitor MS0124

Summary for 5TUZ

• Entry DOI: 10.2210/pdb5tuz/pdb
• Related: 5TUY
• Descriptor: Histone-lysine N-methyltransferase EHMT1, S-ADENOSYLMETHIONINE, ZINC ION, ... (6 entities in total)
• Functional Keywords: methyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 62683.98

Authors

Babault, N.,Xiong, Y.,Liu, J.,Jin, J. (deposition date: 2016-11-07, release date: 2017-02-22, Last modification date: 2023-10-04)

• Primary citation: Xiong, Y.,Li, F.,Babault, N.,Dong, A.,Zeng, H.,Wu, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J.; Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.; J. Med. Chem., 60:1876-1891, 2017; PubMed: 28135087; DOI: 10.1021/acs.jmedchem.6b01645

Experimental method

X-RAY DIFFRACTION (1.95 Å)