5TUZ
Structure of human GLP SET-domain (EHMT1) in complex with inhibitor MS0124
Summary for 5TUZ
Entry DOI | 10.2210/pdb5tuz/pdb |
Related | 5TUY |
Descriptor | Histone-lysine N-methyltransferase EHMT1, S-ADENOSYLMETHIONINE, ZINC ION, ... (6 entities in total) |
Functional Keywords | methyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 62683.98 |
Authors | Babault, N.,Xiong, Y.,Liu, J.,Jin, J. (deposition date: 2016-11-07, release date: 2017-02-22, Last modification date: 2023-10-04) |
Primary citation | Xiong, Y.,Li, F.,Babault, N.,Dong, A.,Zeng, H.,Wu, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J. Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J. Med. Chem., 60:1876-1891, 2017 Cited by PubMed: 28135087DOI: 10.1021/acs.jmedchem.6b01645 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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