5TTS
Jak3 with covalent inhibitor 4
Summary for 5TTS
Entry DOI | 10.2210/pdb5tts/pdb |
Related | 5TTU 5TTV |
Descriptor | Tyrosine-protein kinase JAK3, 1-{(3R)-3-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one (3 entities in total) |
Functional Keywords | kinase, covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : P52333 |
Total number of polymer chains | 1 |
Total formula weight | 36816.99 |
Authors | Vajdos, F.F. (deposition date: 2016-11-04, release date: 2017-02-22, Last modification date: 2017-03-22) |
Primary citation | Thorarensen, A.,Dowty, M.E.,Banker, M.E.,Juba, B.,Jussif, J.,Lin, T.,Vincent, F.,Czerwinski, R.M.,Casimiro-Garcia, A.,Unwalla, R.,Trujillo, J.I.,Liang, S.,Balbo, P.,Che, Y.,Gilbert, A.M.,Brown, M.F.,Hayward, M.,Montgomery, J.,Leung, L.,Yang, X.,Soucy, S.,Hegen, M.,Coe, J.,Langille, J.,Vajdos, F.,Chrencik, J.,Telliez, J.B. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. J. Med. Chem., 60:1971-1993, 2017 Cited by PubMed: 28139931DOI: 10.1021/acs.jmedchem.6b01694 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
Download full validation report