5TTO

X-ray crystal structure of PPARgamma in complex with SR1643

5TTO の概要

• エントリーDOI: 10.2210/pdb5tto/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 4-bromo-N-{3,5-dichloro-4-[(quinolin-3-yl)oxy]phenyl}-2,5-difluorobenzene-1-sulfonamide (3 entities in total)
• 機能のキーワード: nuclear receptor, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63536.86

構造登録者

Bruning, J.B.,Frkic, R.L.,Griffin, P.,Kamenecka, T.,Abell, A. (登録日: 2016-11-04, 公開日: 2017-05-24, 最終更新日: 2023-10-04)

• 主引用文献: Frkic, R.L.,He, Y.,Rodriguez, B.B.,Chang, M.R.,Kuruvilla, D.,Ciesla, A.,Abell, A.D.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B.; Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPAR gamma-Targeted Antidiabetics.; J. Med. Chem., 60:4584-4593, 2017; PubMed: 28485590; DOI: 10.1021/acs.jmedchem.6b01727

実験手法

X-RAY DIFFRACTION (2.246 Å)