5TTG
Crystal structure of catalytic domain of GLP with MS012
Summary for 5TTG
Entry DOI | 10.2210/pdb5ttg/pdb |
Related | 5TTF |
Descriptor | Histone-lysine N-methyltransferase EHMT1, S-ADENOSYLMETHIONINE, N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine, ... (9 entities in total) |
Functional Keywords | ehmt1, glp, ms012, methyltransferase, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q9H9B1 |
Total number of polymer chains | 2 |
Total formula weight | 68277.61 |
Authors | DONG, A.,ZENG, H.,LIU, J.,XIONG, Y.,BABAULT, N.,JIN, J.,TEMPEL, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,WU, H.,BROWN, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2016-11-03, release date: 2017-02-01, Last modification date: 2023-10-04) |
Primary citation | Xiong, Y.,Li, F.,Babault, N.,Dong, A.,Zeng, H.,Wu, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J. Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J. Med. Chem., 60:1876-1891, 2017 Cited by PubMed: 28135087DOI: 10.1021/acs.jmedchem.6b01645 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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