5TQU

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor

5TQU の概要

• エントリーDOI: 10.2210/pdb5tqu/pdb
• 分子名称: Methionyl-tRNA synthetase, putative, METHIONINE, 2-[2-[[3-(1~{H}-benzimidazol-2-ylamino)propylamino]methyl]-4,6-bis(chloranyl)indol-1-yl]ethanol, ... (6 entities in total)
• 機能のキーワード: synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123431.14

構造登録者

Barros-Alvarez, X.,Hol, W.G.J. (登録日: 2016-10-24, 公開日: 2017-04-12, 最終更新日: 2023-10-04)

• 主引用文献: Devine, W.G.,Diaz-Gonzalez, R.,Ceballos-Perez, G.,Rojas, D.,Satoh, T.,Tear, W.,Ranade, R.M.,Barros-Alvarez, X.,Hol, W.G.,Buckner, F.S.,Navarro, M.,Pollastri, M.P.; From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.; ACS Infect Dis, 3:225-236, 2017; PubMed: 28110521; DOI: 10.1021/acsinfecdis.6b00202

実験手法

X-RAY DIFFRACTION (2.6 Å)