5TP9
Structure of the human GluN1/GluN2A LBD in complex with compound 2 (GNE9178)
Summary for 5TP9
Entry DOI | 10.2210/pdb5tp9/pdb |
Related | 5TPA |
Descriptor | Glutamate receptor ionotropic, NMDA 2A, Glutamate receptor ionotropic, NMDA 1, ACETATE ION, ... (8 entities in total) |
Functional Keywords | nmda receptor, glutamate, glycine, calcium channel, membrane, transport protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: Q12879 Q05586 |
Total number of polymer chains | 2 |
Total formula weight | 66033.64 |
Authors | Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2016-10-20, release date: 2016-11-30, Last modification date: 2017-02-08) |
Primary citation | Villemure, E.,Volgraf, M.,Jiang, Y.,Wu, G.,Ly, C.Q.,Yuen, P.W.,Lu, A.,Luo, X.,Liu, M.,Zhang, S.,Lupardus, P.J.,Wallweber, H.J.,Liederer, B.M.,Deshmukh, G.,Plise, E.,Tay, S.,Wang, T.M.,Hanson, J.E.,Hackos, D.H.,Scearce-Levie, K.,Schwarz, J.B.,Sellers, B.D. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett, 8:84-89, 2017 Cited by PubMed: 28105280DOI: 10.1021/acsmedchemlett.6b00388 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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