5TNR

Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 16,17-EpDPE hydrolysis intermediate

5TNR の概要

• エントリーDOI: 10.2210/pdb5tnr/pdb
• 関連するPDBエントリー: 5TNF 5TNG 5TNH 5TNL 5TNM 5TNN 5TNS
• 分子名称: CFTR inhibitory factor, (4Z,7Z,10Z,13Z,16R,17R,19Z)-16,17-dihydroxydocosa-4,7,10,13,19-pentaenoic acid (3 entities in total)
• 機能のキーワード: epoxide hydrolase, hydroxyalkyl-enzyme intermediate, hydrolase
• 由来する生物種: Pseudomonas aeruginosa (strain UCBPP-PA14)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 138104.87

構造登録者

Hvorecny, K.L.,Madden, D.R. (登録日: 2016-10-14, 公開日: 2017-10-18, 最終更新日: 2023-10-04)

• 主引用文献: Hvorecny, K.L.,Bahl, C.D.,Kitamura, S.,Lee, K.S.S.,Hammock, B.D.,Morisseau, C.,Madden, D.R.; Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.; Structure, 25:697-707.e4, 2017; PubMed: 28392259; DOI: 10.1016/j.str.2017.03.002

実験手法

X-RAY DIFFRACTION (1.8 Å)