5TMN

Slow-and fast-binding inhibitors of thermolysin display different modes of binding. crystallographic analysis of extended phosphonamidate transition-state analogues

5TMN の概要

• エントリーDOI: 10.2210/pdb5tmn/pdb
• 関連するPDBエントリー: 4TMN
• 関連するBIRD辞書のPRD_ID: PRD_000654
• 分子名称: THERMOLYSIN, N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-leucine, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: metalloproteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bacillus thermoproteolyticus
• 細胞内の位置: Secreted: P00800
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35059.51

構造登録者

Holden, H.M.,Tronrud, D.E.,Monzingo, A.F.,Weaver, L.H.,Matthews, B.W. (登録日: 1987-06-29, 公開日: 1989-01-09, 最終更新日: 2022-11-23)

• 主引用文献: Holden, H.M.,Tronrud, D.E.,Monzingo, A.F.,Weaver, L.H.,Matthews, B.W.; Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues.; Biochemistry, 26:8542-8553, 1987; PubMed: 3442675; DOI: 10.1021/bi00400a008

実験手法

X-RAY DIFFRACTION (1.6 Å)