5TMM

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC analog, (E)-6-(4-((1R,4S,6R)-6-((4-bromophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)hex-5-enoic acid

5TMM の概要

• エントリーDOI: 10.2210/pdb5tmm/pdb
• 関連するPDBエントリー: 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8
• 分子名称: Estrogen receptor, Nuclear receptor coactivator 2, 6-{4-[(1S,4S,6S)-6-[(4-bromophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl}hex-5-enoic acid, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372; Nucleus: Q15596
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62981.80

構造登録者

Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. (登録日: 2016-10-13, 公開日: 2017-01-18, 最終更新日: 2024-03-06)

• 主引用文献: Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Wright, N.J.,Minutolo, F.,Rangarajan, E.S.,Izard, T.,Yao, X.Q.,Grant, B.J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W.; Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.; Cell Chem Biol, 24:35-45, 2017; PubMed: 28042045; DOI: 10.1016/j.chembiol.2016.11.014

実験手法

X-RAY DIFFRACTION (2.2 Å)