5TI9

Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161

5TI9 の概要

• エントリーDOI: 10.2210/pdb5ti9/pdb
• 関連するPDBエントリー: 5TIA
• 分子名称: Tryptophan 2,3-dioxygenase, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
• 機能のキーワード: human tryptophan 2, 3-dioxygenase in complex with trp and o2, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 185147.83

構造登録者

Forouhar, F.,Lewis-Ballester, A.,Lew, S.,Karkashon, S.,Seetharaman, J.,Yeh, S.R.,Tong, L. (登録日: 2016-10-01, 公開日: 2016-10-26, 最終更新日: 2023-11-15)

• 主引用文献: Lewis-Ballester, A.,Forouhar, F.,Kim, S.M.,Lew, S.,Wang, Y.,Karkashon, S.,Seetharaman, J.,Batabyal, D.,Chiang, B.Y.,Hussain, M.,Correia, M.A.,Yeh, S.R.,Tong, L.; Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase.; Sci Rep, 6:35169-35169, 2016; PubMed: 27762317; DOI: 10.1038/srep35169

実験手法

X-RAY DIFFRACTION (2.5 Å)