5TFW
Crystal structure of 10E8 Fab light chain mutant2 against the MPER region of the HIV-1 Env, in complex with T117v2 epitope scaffold
Summary for 5TFW
Entry DOI | 10.2210/pdb5tfw/pdb |
Descriptor | Antibody 10E8 FAB HEAVY CHAIN, Antibody 10E8 FAB LIGHT CHAIN MUTANT2, 10E8 EPITOPE SCAFFOLD T117V2, ... (6 entities in total) |
Functional Keywords | hiv-1 gp41 mper, 10e8 fab, lipid membrane, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 67121.86 |
Authors | Irimia, A.,Wilson, I.A. (deposition date: 2016-09-26, release date: 2017-03-08, Last modification date: 2023-10-04) |
Primary citation | Irimia, A.,Serra, A.M.,Sarkar, A.,Jacak, R.,Kalyuzhniy, O.,Sok, D.,Saye-Francisco, K.L.,Schiffner, T.,Tingle, R.,Kubitz, M.,Adachi, Y.,Stanfield, R.L.,Deller, M.C.,Burton, D.R.,Schief, W.R.,Wilson, I.A. Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design. PLoS Pathog., 13:e1006212-e1006212, 2017 Cited by PubMed: 28225819DOI: 10.1371/journal.ppat.1006212 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.168 Å) |
Structure validation
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