5TFW

Crystal structure of 10E8 Fab light chain mutant2 against the MPER region of the HIV-1 Env, in complex with T117v2 epitope scaffold

5TFW の概要

• エントリーDOI: 10.2210/pdb5tfw/pdb
• 分子名称: Antibody 10E8 FAB HEAVY CHAIN, Antibody 10E8 FAB LIGHT CHAIN MUTANT2, 10E8 EPITOPE SCAFFOLD T117V2, ... (6 entities in total)
• 機能のキーワード: hiv-1 gp41 mper, 10e8 fab, lipid membrane, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 67121.86

構造登録者

Irimia, A.,Wilson, I.A. (登録日: 2016-09-26, 公開日: 2017-03-08, 最終更新日: 2023-10-04)

• 主引用文献: Irimia, A.,Serra, A.M.,Sarkar, A.,Jacak, R.,Kalyuzhniy, O.,Sok, D.,Saye-Francisco, K.L.,Schiffner, T.,Tingle, R.,Kubitz, M.,Adachi, Y.,Stanfield, R.L.,Deller, M.C.,Burton, D.R.,Schief, W.R.,Wilson, I.A.; Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.; PLoS Pathog., 13:e1006212-e1006212, 2017; PubMed: 28225819; DOI: 10.1371/journal.ppat.1006212

実験手法

X-RAY DIFFRACTION (2.168 Å)