5TFT
Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex
Summary for 5TFT
Entry DOI | 10.2210/pdb5tft/pdb |
Related | 5T1U 5TFT |
Descriptor | Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, ... (5 entities in total) |
Functional Keywords | cyp2d6, p450 2d6, cytochrome p450, monooxygenase, bace1, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 219232.82 |
Authors | Hsu, M.H.,Johnson, E.F. (deposition date: 2016-09-26, release date: 2017-01-11, Last modification date: 2023-10-04) |
Primary citation | Butler, C.R.,Ogilvie, K.,Martinez-Alsina, L.,Barreiro, G.,Beck, E.M.,Nolan, C.E.,Atchison, K.,Benvenuti, E.,Buzon, L.,Doran, S.,Gonzales, C.,Helal, C.J.,Hou, X.,Hsu, M.H.,Johnson, E.F.,Lapham, K.,Lanyon, L.,Parris, K.,O'Neill, B.T.,Riddell, D.,Robshaw, A.,Vajdos, F.,Brodney, M.A. Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality. J. Med. Chem., 60:386-402, 2017 Cited by PubMed: 27997172DOI: 10.1021/acs.jmedchem.6b01451 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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