5TF9
Crystal structure of WNK1 in complex with Mn2+AMPPNP and WNK476
Summary for 5TF9
Entry DOI | 10.2210/pdb5tf9/pdb |
Descriptor | Serine/threonine-protein kinase WNK1, {2-[(4-chlorophenyl)methoxy]phenyl}{5-[2-(methylamino)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indol-1-yl}methanone, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total) |
Functional Keywords | serine-threonine-protein kinase, inhibitor, ternary, complex, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9H4A3 |
Total number of polymer chains | 2 |
Total formula weight | 65902.15 |
Authors | Xie, X.,Gunawan, J. (deposition date: 2016-09-24, release date: 2016-10-19, Last modification date: 2023-10-04) |
Primary citation | Yamada, K.,Zhang, J.H.,Xie, X.,Reinhardt, J.,Xie, A.Q.,LaSala, D.,Kohls, D.,Yowe, D.,Burdick, D.,Yoshisue, H.,Wakai, H.,Schmidt, I.,Gunawan, J.,Yasoshima, K.,Yue, Q.K.,Kato, M.,Mogi, M.,Idamakanti, N.,Kreder, N.,Drueckes, P.,Pandey, P.,Kawanami, T.,Huang, W.,Yagi, Y.I.,Deng, Z.,Park, H.M. Discovery and Characterization of Allosteric WNK Kinase Inhibitors. ACS Chem. Biol., 11:3338-3346, 2016 Cited by PubMed: 27712055DOI: 10.1021/acschembio.6b00511 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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