5TE7

Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade C Strain DU172.17 gp120 Core

5TE7 の概要

• エントリーDOI: 10.2210/pdb5te7/pdb
• 関連するPDBエントリー: 5TE4 5TE6
• 分子名称: Heavy chain of N6, Light chain of N6, HIV-1 gp120 core, ... (7 entities in total)
• 機能のキーワード: hiv-1, vrc01-class antibody, n6, cd4-binding site, gp120, immune system
• 由来する生物種: Homo sapiens (HUman); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 89023.04

構造登録者

Zhou, T.,Kwong, P.D. (登録日: 2016-09-20, 公開日: 2016-11-16, 最終更新日: 2023-10-04)

• 主引用文献: Huang, J.,Kang, B.H.,Ishida, E.,Zhou, T.,Griesman, T.,Sheng, Z.,Wu, F.,Doria-Rose, N.A.,Zhang, B.,McKee, K.,O'Dell, S.,Chuang, G.Y.,Druz, A.,Georgiev, I.S.,Schramm, C.A.,Zheng, A.,Joyce, M.G.,Asokan, M.,Ransier, A.,Darko, S.,Migueles, S.A.,Bailer, R.T.,Louder, M.K.,Alam, S.M.,Parks, R.,Kelsoe, G.,Von Holle, T.,Haynes, B.F.,Douek, D.C.,Hirsch, V.,Seaman, M.S.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.,Connors, M.; Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.; Immunity, 45:1108-1121, 2016; PubMed: 27851912; DOI: 10.1016/j.immuni.2016.10.027

実験手法

X-RAY DIFFRACTION (2.15 Å)