5TDI

Crystal structure of Cathepsin K with a covalently-linked inhibitor at 1.4 Angstrom resolution.

5TDI の概要

• エントリーDOI: 10.2210/pdb5tdi/pdb
• 分子名称: Cathepsin K, 4-fluoro-N-{1-[(Z)-iminomethyl]cyclopropyl}-N~2~-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl }-L-leucinamide (3 entities in total)
• 機能のキーワード: cathepsin k, covalent, inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24035.06

構造登録者

Law, S.,Aguda, A.,Nguyen, N.,Brayer, G.,Bromme, D. (登録日: 2016-09-19, 公開日: 2017-01-25, 最終更新日: 2023-10-04)

• 主引用文献: Law, S.,Andrault, P.M.,Aguda, A.H.,Nguyen, N.T.,Kruglyak, N.,Brayer, G.D.,Bromme, D.; Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib.; Biochem. J., 474:851-864, 2017; PubMed: 28049758; DOI: 10.1042/BCJ20160985

実験手法

X-RAY DIFFRACTION (1.4 Å)