5TCZ

NMR solution structure of engineered Protoxin-II analog

Summary for 5TCZ

DescriptorBeta/omega-theraphotoxin-Tp2a (1 entity in total)
Functional Keywordsvenom peptide analog, inhibitor, cystine knot, toxin
Biological sourceThrixopelma pruriens (Peruvian green velvet tarantula)
Total number of polymer chains1
Total molecular weight3862.72
Authors
Gibbs, A.C.,Wickenden, A.D. (deposition date: 2016-09-16, release date: 2017-01-18)
Primary citation
Flinspach, M.,Xu, Q.,Piekarz, A.D.,Fellows, R.,Hagan, R.,Gibbs, A.,Liu, Y.,Neff, R.A.,Freedman, J.,Eckert, W.A.,Zhou, M.,Bonesteel, R.,Pennington, M.W.,Eddinger, K.A.,Yaksh, T.L.,Hunter, M.,Swanson, R.V.,Wickenden, A.D.
Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.
Sci Rep, 7:39662-39662, 2017
PubMed: 28045073 (PDB entries with the same primary citation)
DOI: 10.1038/srep39662
MImport into Mendeley
Experimental method
SOLUTION NMR
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers07.4%19.8%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures