5TCO

Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1

5TCO の概要

• エントリーDOI: 10.2210/pdb5tco/pdb
• 関連するPDBエントリー: 5TBE
• 分子名称: Mitogen-activated protein kinase 14, 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-5,6-dihydrodibenzo[1,2-~{d}:1',2'-~{f}][7]annulene-9-carboxamide, octyl beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: inhibitor, dibenzosuberone, human p38 map kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42446.45

構造登録者

Mayer-Wrangowski, S.C.,Rauh, D. (登録日: 2016-09-15, 公開日: 2017-04-19, 最終更新日: 2020-07-29)

• 主引用文献: Wentsch, H.K.,Walter, N.M.,Buhrmann, M.,Mayer-Wrangowski, S.,Rauh, D.,Zaman, G.J.R.,Willemsen-Seegers, N.,Buijsman, R.C.,Henning, M.,Dauch, D.,Zender, L.,Laufer, S.; Optimized Target Residence Time: Type I1/2 Inhibitors for p38 alpha MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.; Angew. Chem. Int. Ed. Engl., 56:5363-5367, 2017; PubMed: 28397331; DOI: 10.1002/anie.201701185

実験手法

X-RAY DIFFRACTION (2.1 Å)