5TB6
Structure of bromodomain of CREBBP with a pyrazolo[4,3-c]pyridin fragment
Summary for 5TB6
Entry DOI | 10.2210/pdb5tb6/pdb |
Descriptor | CREB-binding protein, 1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)propan-1-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | fragment, complex, bromodomain, structural genomics, structural genomics consortium, sgc, trasnferase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q92793 |
Total number of polymer chains | 1 |
Total formula weight | 14540.73 |
Authors | Filippakopoulos, P.,Picaud, S.,Knapp, S.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Structural Genomics Consortium (SGC) (deposition date: 2016-09-11, release date: 2016-10-12, Last modification date: 2024-01-17) |
Primary citation | Navratilova, I.,Aristotelous, T.,Picaud, S.,Chaikuad, A.,Knapp, S.,Filappakopoulos, P.,Hopkins, A.L. Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. ACS Med Chem Lett, 7:1213-1218, 2016 Cited by PubMed: 27994766DOI: 10.1021/acsmedchemlett.6b00154 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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