5TB6

Structure of bromodomain of CREBBP with a pyrazolo[4,3-c]pyridin fragment

5TB6 の概要

• エントリーDOI: 10.2210/pdb5tb6/pdb
• 分子名称: CREB-binding protein, 1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)propan-1-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: fragment, complex, bromodomain, structural genomics, structural genomics consortium, sgc, trasnferase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q92793
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14540.73

構造登録者

Filippakopoulos, P.,Picaud, S.,Knapp, S.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Structural Genomics Consortium (SGC) (登録日: 2016-09-11, 公開日: 2016-10-12, 最終更新日: 2024-01-17)

• 主引用文献: Navratilova, I.,Aristotelous, T.,Picaud, S.,Chaikuad, A.,Knapp, S.,Filappakopoulos, P.,Hopkins, A.L.; Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.; ACS Med Chem Lett, 7:1213-1218, 2016; PubMed: 27994766; DOI: 10.1021/acsmedchemlett.6b00154

実験手法

X-RAY DIFFRACTION (1.79 Å)