5T7X

Crystal structure of HHV-4 EBNA1 DNA binding domain (patient-derived, nasopharyngeal carcinoma) bound to DNA

Summary for 5T7X

• Entry DOI: 10.2210/pdb5t7x/pdb
• Descriptor: DNA (5'-D(*GP*GP*AP*TP*AP*GP*CP*CP*TP*AP*TP*GP*CP*TP*AP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*TP*AP*GP*CP*AP*TP*AP*GP*GP*CP*TP*AP*TP*CP*C)-3'), Epstein-Barr nuclear antigen 1, ... (4 entities in total)
• Functional Keywords: dimer, dna, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Human herpesvirus 4 (strain B95-8) (HHV-4); More
• Cellular location: Host nucleus : Q3KSS4
• Total number of polymer chains: 4
• Total formula weight: 43697.19

Authors

Malecka, K.A.,Messick, T.E.,Lieberman, P.M. (deposition date: 2016-09-06, release date: 2017-07-19, Last modification date: 2023-10-04)

• Primary citation: Dheekollu, J.,Malecka, K.,Wiedmer, A.,Delecluse, H.J.,Chiang, A.K.,Altieri, D.C.,Messick, T.E.,Lieberman, P.M.; Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.; Oncotarget, 8:7248-7264, 2017; PubMed: 28077791; DOI: 10.18632/oncotarget.14540

Experimental method

X-RAY DIFFRACTION (2.35 Å)