5T5T
AMPK bound to allosteric activator
Summary for 5T5T
Entry DOI | 10.2210/pdb5t5t/pdb |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total) |
Functional Keywords | ampk, kinase, allostery, activator, transferase |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasm : P54645 |
Total number of polymer chains | 3 |
Total formula weight | 120500.96 |
Authors | Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2016-08-31, release date: 2017-03-29, Last modification date: 2023-10-04) |
Primary citation | Salatto, C.T.,Miller, R.A.,Cameron, K.O.,Cokorinos, E.,Reyes, A.,Ward, J.,Calabrese, M.F.,Kurumbail, R.G.,Rajamohan, F.,Kalgutkar, A.S.,Tess, D.A.,Shavnya, A.,Genung, N.E.,Edmonds, D.J.,Jatkar, A.,Maciejewski, B.S.,Amaro, M.,Gandhok, H.,Monetti, M.,Cialdea, K.,Bollinger, E.,Kreeger, J.M.,Coskran, T.M.,Opsahl, A.C.,Boucher, G.G.,Birnbaum, M.J.,DaSilva-Jardine, P.,Rolph, T. Selective Activation of AMPK beta 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. J. Pharmacol. Exp. Ther., 361:303-311, 2017 Cited by PubMed: 28289077DOI: 10.1124/jpet.116.237925 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.46 Å) |
Structure validation
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