5T5D

Crystal Structure of the PTS IIB protein associated with the fucose utilization operon from Streptococcus pneumoniae

5T5D の概要

• エントリーDOI: 10.2210/pdb5t5d/pdb
• 分子名称: PTS system, IIB component (2 entities in total)
• 機能のキーワード: transport, transport protein
• 由来する生物種: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18513.50

構造登録者

Higgins, M.A.,Boraston, A.B. (登録日: 2016-08-30, 公開日: 2016-10-26, 最終更新日: 2024-03-06)

主引用文献

Higgins, M.A.,Hamilton, A.M.,Boraston, A.B.
Structural characterization of the PTS IIA and IIB proteins associated with pneumococcal fucose utilization.
Proteins, 85:963-968, 2017

PubMed Abstract: Streptococcus pneumoniae harbors a significant number of transporters, including phosphotransferase (PTS) systems, allowing the bacterium to utilize a number of different carbohydrates for metabolic and other purposes. The genes encoding for one PTS transport system in particular (EII ) are found within a fucose utilization operon in S. pneumoniae TIGR4. Here, we report the three-dimensional structures of IIA and IIB providing evidence that this PTS system belongs to the EII family. Additionally, the predicted metabolic pathway for this distinctive fucose utilization system suggests that EII transports the H-disaccharide blood group antigen, which would represent a novel PTS transporter specificity. Proteins 2017; 85:963-968. © 2016 Wiley Periodicals, Inc.

PubMed: 28168775
DOI: 10.1002/prot.25264

実験手法

X-RAY DIFFRACTION (2.5 Å)