5T3X

3.9 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074.

これはPDB形式変換不可エントリーです。

5T3X の概要

• エントリーDOI: 10.2210/pdb5t3x/pdb
• 関連するPDBエントリー: 5T3Z
• 分子名称: Envelope glycoprotein gp160, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (23 entities in total)
• 機能のキーワード: hiv, n-linked glycosylation, broadly neutralizing antibodies, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 189016.93

構造登録者

Gristick, H.B.,Bjorkman, P.J. (登録日: 2016-08-26, 公開日: 2016-10-05, 最終更新日: 2023-10-04)

• 主引用文献: Gristick, H.B.,von Boehmer, L.,West, A.P.,Schamber, M.,Gazumyan, A.,Golijanin, J.,Seaman, M.S.,Fatkenheuer, G.,Klein, F.,Nussenzweig, M.C.,Bjorkman, P.J.; Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site.; Nat.Struct.Mol.Biol., 23:906-915, 2016; PubMed: 27617431; DOI: 10.1038/nsmb.3291

実験手法

X-RAY DIFFRACTION (3.9 Å)