5T35
The PROTAC MZ1 in complex with the second bromodomain of Brd4 and pVHL:ElonginC:ElonginB
Summary for 5T35
| Entry DOI | 10.2210/pdb5t35/pdb |
| Descriptor | Bromodomain-containing protein 4, Transcription elongation factor B polypeptide 2, Transcription elongation factor B polypeptide 1, ... (6 entities in total) |
| Functional Keywords | protac complex, targeted degradation, chromatin reader, ubiquitin ligase, bifunctional ligand, ligase |
| Biological source | Homo sapiens (Human) More |
| Cellular location | Nucleus: O60885 Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337 |
| Total number of polymer chains | 8 |
| Total formula weight | 114980.60 |
| Authors | Gadd, M.S.,Zengerle, M.,Ciulli, A. (deposition date: 2016-08-24, release date: 2017-03-08, Last modification date: 2024-01-17) |
| Primary citation | Gadd, M.S.,Testa, A.,Lucas, X.,Chan, K.H.,Chen, W.,Lamont, D.J.,Zengerle, M.,Ciulli, A. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat. Chem. Biol., 13:514-521, 2017 Cited by PubMed: 28288108DOI: 10.1038/nchembio.2329 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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