5SXN
Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors
Summary for 5SXN
Entry DOI | 10.2210/pdb5sxn/pdb |
Related | 5SY2 5SY3 5SZ9 |
Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(furan-2-yl)methyl]-2-phenylquinazolin-4-amine, ... (7 entities in total) |
Functional Keywords | protein-ligand complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 75617.07 |
Authors | Snell, G.P.,Behnke, C.A.,Okada, K.,Hideyuki, O.,Sang, B.-C.,Lane, W. (deposition date: 2016-08-09, release date: 2016-11-02, Last modification date: 2020-07-29) |
Primary citation | Imaeda, Y.,Tawada, M.,Suzuki, S.,Tomimoto, M.,Kondo, M.,Tarui, N.,Sanada, T.,Kanagawa, R.,Snell, G.,Behnke, C.A.,Kubo, K.,Kuroita, T. Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors. Bioorg.Med.Chem., 24:5771-5780, 2016 Cited by PubMed: 27687967DOI: 10.1016/j.bmc.2016.09.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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